Well, I think first off, tell us what it is you want to sell.
Then, you can procede to Ebay ...
Anything you are really really interested in?
There are a lot of knowledgeable people here to help you along. But you must first do your homework! I would even suggest to take an entrepreneur class and accounting class at a local community college or something online if you are new to the business world.
As for hot items? The Hot List changes by the hour...only expierence can teach you what to sell. Watch the shoppers at Walmart or Target..what are they buying..what are people wearing, whats in the top of the news..all these will tell you what the customer is looking for.