Different areas in the world have different regions, this link will tell you what you need to know in regards to regions.
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In regards to eBay, I started in Second Hand myself and grew from there. Now I have narrowed down that genre in general terms and now specialise, as well as diversified into new products within my online market.
Second Hand is such a great area to get into, endless resources available such as weekend markets, auction house and garage (yard) sales. Not only can you find great deals through these places, if you can talk a good deal, then you can walk away with some sensational buys!
It's not a very popular resource these days because most people don't want to make the effort of leaving their computer for more than a toilet break, hence you have thousands and thousands of people all tripping over themselves to find the same products online.
Most of my business is now done off eBay, but I do have a small eBay business going on the side, just because I would miss it too much if I had no presence there at all lol.