It really does depend on the types of products where eBay is concerned. You're going up against all sorts of sellers, everything from solo sellers right through to large wholesalers themselves, who will sell to you as a supplier outside of eBay, then compete against you on eBay.
It's all about finding market space, and that comes down to finding a product that is available to you at the right price and one that has potential to find a market on eBay.
It's never an easy equation to work out, and the worst part is that's only the start. This is one tough business to be in and it's just getting harder and harder to find some market-share as more and more people move into the area of online sales.
As far as suggestions go, the obvious one seems to be that you need to look at different products or at the least different suppliers for those products. Drop Shipping is never going to secure you the best possible price, but you also mention that Wholesale inquiries aren't offering a good price either.
You want to firstly be sure as to who you are getting a wholesale price from as there are plenty of suppliers that will call themselves wholesalers, but in reality are not. If you want to get a genuine wholesale price then you need to talk to a genuine wholesaler who will give you a price based on a particular order quantity.
If you find that a genuine wholesale price still can't get you market-share, then you definitely need to look at different products firstly, and then look at suppliers once more.
Research is king in this type of business and is often where the most dedication is required. When you think you've researched as much as you possibly can, then you need to refuel and research twice a hard most of the time.